3-Quinolinecarboxylic acid, 2,4-dimethyl- - Names and Identifiers
3-Quinolinecarboxylic acid, 2,4-dimethyl- - Physico-chemical Properties
Molecular Formula | C12H11NO2
|
Molar Mass | 201.22 |
Boling Point | 354.1°C at 760 mmHg |
Flash Point | 167.9°C |
Vapor Presure | 1.26E-05mmHg at 25°C |
Storage Condition | 2-8°C |
3-Quinolinecarboxylic acid, 2,4-dimethyl- - Risk and Safety
Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
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Safety Description | 36/37 - Wear suitable protective clothing and gloves.
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HS Code | 29334900 |
3-Quinolinecarboxylic acid, 2,4-dimethyl- - Introduction
2,4-Dimethylquinoline-3-carboxylic acid is an organic compound with the formula C12H13NO2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2,4-Dimethylquinoline-3-carboxylic acid is a colorless or slightly yellow crystalline solid.
-Solubility: It is soluble in organic solvents such as methanol, chloroform and dichloromethane, and has poor solubility with water.
-Melting point: Its melting point is about 126-129°C.
Use:
-2,4-Dimethylquinoline-3-carboxylic acid is commonly used as a pharmaceutical intermediate, which can be used to synthesize a variety of pharmaceutically active compounds.
-It can also be used as a dye intermediate for the synthesis of dyes and pigments.
Preparation Method:
A common preparation method of 2,4-dimethylquinoline-3-carboxylic acid is through the oxidation reaction of 2,4-dimethylquinoline. Specific steps are as follows:
1. Dissolve 2,4-dimethylquinoline in a suitable organic solvent, such as methanol.
2. Slowly add an oxidizing agent, such as potassium permanganate (KMnO4).
3. The reaction is carried out at an appropriate temperature for several hours.
4. The reaction mixture was filtered to obtain a precipitate of 2,4-dimethylquinoline-3-carboxylic acid.
5. Purify the precipitate by crystallization to obtain the pure product.
Safety Information:
-2,4-Dimethylquinoline-3-carboxylic acid is generally stable and safe under normal operating conditions.
-Pay attention to personal protective measures during handling and use, such as wearing gloves, goggles and protective clothing.
-When performing chemical synthesis or reacting with other compounds, care should be taken to avoid the production of toxic or harmful gases, fumes or vapors.
-Waste disposal should be carried out in accordance with local regulations to avoid pollution to the environment.
Last Update:2024-04-09 02:00:40